Rutivi rwekunze runonamira rwefungus nemabhakitiriya, runonzi "extracellular matrix" kana kuti ECM, rune kuenzana kwejelly uye runoshanda serutivi rwekudzivirira negoko. Asi zvichienderana neongororo yakaitwa munguva pfupi yapfuura mumagazini ye iScience, yakaitwa neYunivhesiti yeMassachusetts Amherst pamwe chete neWorcester Polytechnic Institute, ECM yemamwe mabhakitiriya inoumba gel chete kana paine oxalic acid kana mamwe maasidhi ari nyore. Nekuti ECM inoita basa rakakosha mune zvese kubva pakurapwa kwemishonga inorwisa mabhakitiriya kusvika pamapombi akavharika uye kusvibiswa kwemidziyo yekurapa, kunzwisisa kuti mabhakitiriya anodzora sei matanda avo anonamira egel kune zvakunoreva muhupenyu hwedu hwezuva nezuva.

"Ndagara ndichifarira maECM ehutachiona," akadaro Barry Goodell, purofesa we microbiology paYunivhesiti yeMassachusetts Amherst uye munyori mukuru wepepa iri. "Vanhu vanowanzo funga nezveECM sechinhu chinodzivirira chekunze chisingapindi chinodzivirira hutachiona. Asi chinogonawo kushanda senzira yekufambisa zvinovaka muviri nema enzymes mukati nekubuda mumasero ehutachiona."
Kupenda uku kunoita mabasa akati wandei: kunamira kwaro kunoreva kuti tupukanana twunogona kuungana pamwe chete kuti tigadzire koloni kana kuti "biofilms", uye kana tupukanana twakawanda tukaita izvi, tunogona kuvhara mapaipi kana kusvibisa michina yekurapa.
Asi goko rinofanirawo kunyura: tupukanana twakawanda tunoburitsa ma enzyme akasiyana-siyana nezvimwe zvinhu zvinoburitswa kuburikidza neECM, muzvinhu zvavanoda kudya kana kutapurira (zvakadai sehuni dzakaora kana tishu dzemhuka dzine mapfupa), uye kana ma enzyme apedza basa rawo, basa rekugaya - rinodzosera zvinovaka muviri kuburikidza neECM.
Izvi zvinoreva kuti ECM haisi kungodzivirira chete; Kutaura zvazviri, sezvakaratidzwa naGoodell nevamwe vake, tupukanana tunoita setune simba rekudzora kupenya kweECM yavo uye nekudaro kupenya kwayo. Vanozviita sei?
Muhowa, kuburitswa kwacho kunoratidzika kunge kuri oxalic acid, iyo inowanzo shandiswa muzvirimwa zvakawanda, uye, sezvakawanikwa naGoodell nevamwe vake, tupukanana twakawanda tunoita setunoshandisa oxalic acid yatinoburitsa kuti tibatane nemafuta ekunze emacarbohydrates, zvichiita chinhu chinonamira. , ECM yakaita sejelly.
Asi chikwata ichi pachakanyatsoongorora, chakaona kuti oxalic acid haina kungobatsira kugadzira ECM chete, asiwo "yakaidzora": kana mabhakitiriya akawanda akawedzerwa oxalic acid mumusanganiswa wecarbohydrate-acid, ECM inowedzera kusimba. Kana ECM ikawedzera kusimba, ndipo painovhara mamorekuru makuru kuti asapinde kana kubuda muhutachiona, nepo mamorekuru madiki achiramba akasununguka kupinda muhutachiona kubva munzvimbo yakapoteredza uye zvinopesana.
Kuwanikwa uku kunonetsa kunzwisisa kwesainzi kwechinyakare kwekuti mhando dzakasiyana dzemakemikari anoburitswa nefungus nemabhakitiriya anopinda sei kubva kuhutachiona uhu achipinda munharaunda. Goodell nevamwe vake vakataura kuti mune dzimwe nguva hutachiona hunogona kunge huchinyanya kuvimba nekuburitswa kwemamorekuru madiki kuti hurwise matrix kana tishu iyo hutachiona hunovimba nayo kuti hurarame kana kuti huve nehutachiona. Izvi zvinoreva kuti kuburitswa kwemamorekuru madiki kunogonawo kuita basa guru mukukura kwezvirwere kana maenzyme makuru asingakwanise kupfuura nepakati pe microbial extracellular matrix.
"Zvinoita sekuti pane nzvimbo yepakati," akadaro Goodell, "uko tupukanana tunogona kudzora huwandu hweacidity kuti tuenderane nenzvimbo yakati, tichichengetedza mamwe mamorekuru makuru, akadai sema enzymes, ukuwo tichibvumira mamorekuru madiki kuti apfuure nyore nyore neECM. "Kuchinja kweECM ne oxalic acid kungave nzira yekuti tupukanana tuzvidzivirire kubva kumishonga inorwisa mabhakitiriya nemishonga inorwisa mabhakitiriya, sezvo mishonga iyi yakawanda ine mamorekuru makuru kwazvo. Ndiko kugona kugadzirisa uku kunogona kuva kiyi yekukunda chimwe chezvipingamupinyi zvikuru mukurapa nemishonga inorwisa mabhakitiriya, sezvo kushandisa ECM kuti ipinde mumvura kunogona kuvandudza kushanda kwemishonga inorwisa mabhakitiriya nemishonga inorwisa mabhakitiriya.

"Kana tikakwanisa kudzora kugadzirwa kwemakemikari uye kuburitswa kwemaasidhi madiki akadai seoxalate mune mamwe mabhakitiriya, saka tinogonawo kudzora zvinopinda mumasero aya, izvo zvinogona kutibvumira kurapa zvirwere zvakawanda zvemabhakitiriya zviri nani," akadaro Goodell.
Muna Zvita 2022, nyanzvi yezvirwere zvemabhakitiriya Yasu Morita akagamuchira mari kubva kuNational Institutes of Health yekutsigira tsvakurudzo yakanangana nekugadzira mishonga mitsva inoshanda yeTB.

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