Tinoshandisa makuki kuti tivandudze ruzivo rwenyu. Nekuramba muchitsvaga saiti ino, munobvuma kushandisa kwedu makuki. Ruzivo rwakawanda.
Nekudzvanya pakanzi “Bvumira Zvese”, unobvuma kuchengetwa kwemakuki pamudziyo wako kuti uvandudze kufamba kwewebhusaiti, kuongorora mashandisirwo ewebhusaiti, uye kutsigira kupa kwedu zvemukati zvesainzi zvemahara uye zvakavhurika. Ruzivo rwakawanda.
Kuongororwa kweweti kuri nyore kunogona kuona chirwere cheAlzheimer chiri padanho rekutanga here, zvichigadzira nzira yezvirongwa zvekuongorora vanhu vakawanda? Chidzidzo chitsva cheFrontiers in Aging Neuroscience chinoratidza izvi zvechokwadi. Vaongorori vakaedza boka guru revarwere veAlzheimer vane hutano hwakasiyana-siyana uye vanhu vane hutano hwakanaka avo vaive vakajaira kuziva kuti vaone mutsauko uri mu biomarkers yeweti.
Vakaona kuti formic acid iri muweti chiratidzo chekudzikira kwepfungwa uye inogona kuratidza kutanga kwechirwere cheAlzheimer. Nzira dziripo dzekuongorora chirwere cheAlzheimer dzinodhura, hadzina kunaka, uye hadzigoneke kuongororwa nguva nenguva. Izvi zvinoreva kuti varwere vazhinji vanongoonekwa kana zvasvika nguva yekurapwa zvinobudirira. Zvisinei, kuongororwa kweweti kweformic acid kusingakuvadzi, kwakachipa, uye kuri nyore kungave ndiko chaizvo kuri kukumbira vanachiremba kuti vaongorore nekukurumidza.
“Chirwere cheAlzheimer chirwere chisingaperi chinoramba chiripo uye chinokuvadza, zvichireva kuti chinogona kukura uye kuramba chiripo kwemakore akawanda chisati chaonekwa kutadza kuziva zvakanaka,” vanyori vanodaro. “Matanho ekutanga echirwere ichi anoitika chisati chatanga chirwere chepfungwa chisingadzoreki, chinova mukana wekurapa. Nokudaro, kuongororwa kukuru kwechirwere cheAlzheimer muvanhu vakwegura kwakakodzera.”
Saka, kana kupindira nekukurumidza kwakakosha, sei tisina zvirongwa zvekuongorora chirwere cheAlzheimer chiri padanho rekutanga? Dambudziko riri munzira dzekuongorora dziri kushandiswa navanachiremba parizvino. Izvi zvinosanganisira positron emission tomography yeuropi, iyo inodhura uye inoisa varwere panjodzi yemwaranzi. Kunewo bvunzo dze biomarker dzinogona kuona Alzheimer's, asi dzinoda kudhonzwa kweropa kana kupunhwa kwelumbar kuti uwane cerebrospinal fluid, iyo varwere vangave vachinonoka kuishandisa.
Zvisinei, bvunzo dzeweti hadzipindiri uye dziri nyore, zvichiita kuti dzive dzakakodzera kuongororwa kwevanhu vakawanda. Kunyangwe vaongorori vakamboona zviratidzo zveweti zvechirwere cheAlzheimer, hapana chakakodzera kuona matanho ekutanga echirwere, zvichireva kuti mukana wekurapa nekukurumidza hausati wawanikwa.
Vatsvagiri vari shure kwechidzidzo chitsva vakambodzidza nezvechinhu chinonzi formaldehyde sechiratidzo cheweti chechirwere cheAlzheimer. Zvisinei, pane mukana wekuvandudza pakuona chirwere nekukurumidza. Muchidzidzo ichi chazvino, vakatarisa paformate, metabolite yeformaldehyde, kuti vaone kana ichishanda zviri nani sechiratidzo cheweti.
Vanhu vanosvika 574 vakapinda muchidzidzo ichi, uye vatori vechikamu vaive vakazvipira vane hutano hwakanaka kana kuti vaive nematanho akasiyana-siyana ekufambira mberi kwechirwere, kubva pakudzikira kwepfungwa kusvika pakurwara zvachose. Vaongorori vakaongorora weti neropa kubva kune vatori vechikamu uye vakaita ongororo yepfungwa.
Ongororo iyi yakawana kuti huwandu hweasidhi yemuweti hwakakwira zvakanyanya mumapoka ese ezvirwere zveAlzheimer uye hwakabatana nekuderera kwekuziva kana tichienzanisa neboka revanhu vane hutano, kusanganisira boka rekutanga rekudzikira kwekuziva. Izvi zvinoratidza kuti asidhi yemuweti inogona kushanda sechiratidzo chinonzwisisika chematanho ekutanga echirwere cheAlzheimer.
Zvinofadza kuti, vaongorori pavakaongorora huwandu hwemaforme emuweti pamwe chete nezviratidzo zveropa reAlzheimer, vakaona kuti vaigona kufanotaura zvakanyatsonaka danho rechirwere chiri kurwara nemurwere. Zvisinei, tsvakiridzo yakawanda inodiwa kuti tinzwisise hukama huripo pakati pechirwere cheAlzheimer neformic acid.
“Urine formic acid yakaratidza kunzwa kwakanaka kwazvo pakuongororwa kwechirwere cheAlzheimer nekukurumidza,” vanyori vanodaro. “Kuongororwa kwechirwere cheAlzheimer uchishandisa weti kuri nyore uye kunodhura zvishoma uye kunofanira kuverengerwa mukuongororwa kwehutano hwenguva dzose kwevakwegura.”
Wang, Y. nevamwe. (2022) Ongororo yakarongeka yeformic acid yemuweti sechiratidzo chitsva chinogona kuratidza chirwere cheAlzheimer's. Miganhu mu neurobiology yekukwegura. doi.org/10.3389/fnagi.2022.1046066.
Matagi: kukwegura, chirwere cheAlzheimer, zviratidzo zveropa, ropa, uropi, chisingaperi, zvirwere zvisingaperi, mishonga, dementia, kuongororwa, vanachiremba, formaldehyde, neurology, positron emission tomography, tsvakurudzo, tomography, weti test
PaPittcon 2023 muPhiladelphia, Pennsylvania, takabvunzurudza Purofesa Joseph Wang, akahwina mubairo weRalph N. Adams Prize muAnalytical Chemistry wegore rino, nezvekushanda nesimba kwetekinoroji yebiosensor.
Mubvunzurudzo iyi, tinokurukura nezve biopsy yekufema uye kuti inogona sei kuva chishandiso chinobatsira kudzidza zviratidzo zvekuongorora chirwere nekukurumidza naMariana Leal, Mutungamiriri weChikwata kuOwlstone Medical.
Sechikamu cheongororo yedu yeSLAS US 2023, tinokurukura nezverabhoritari yeramangwana uye kuti ingataridzika sei naLuigi Da Via, Mutungamiriri weGSK Test Development Team.
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